Tissue-engineered liver using primary hepatocytes has been considered a valuable new therapeuticmodality as an alternative to whole organ liver transplantation for different liver diseases. The develo

Three-dimensional (3D) culture of hepatocytes leads to improved and prolonged synthetic andmetabolic functions, but the underlying molecular mechanisms are unknown. In order toinvestigate the role of

Embryonic stem (ES) cells are considered a potentially advantageous source of hepatocytes for bothtransplantation and the development of bioartificial livers. However, the efficient large-scale genera

Mesenchymal stem cells (MSCs) are primary candidates in cell therapy and tissue engineering and are beingtested in clinical trials for a wide range of diseases. Originally isolated and expanded as pla

Background: Exosomes derived from stem cells have been demonstrated to be good candidates for the treatment ofosteochondral injury. Our previous studies have demonstrated that mechanical stimulation c

Surface modification of biodegradable vascular grafts is an important strategy to improve the in situendothelialization of tissue engineered vascular grafts (TEVGs) and prevent major complications ass

As a serious malignant tumour disease, lung cancer is usually accompaniedwith strong clinical manifestation.1,2 The average survival time oflung cancer patients lasts only for several months, even wit

Cancer cells undergo comprehensive metabolic reprogramming to meet the increasedrequirements of energy and building blocks for proliferation. Lipin-1,a phosphatidic acid phosphatase converting phospha

Human induced pluripotent stem (iPS) cell-derived hepatocyte-like cells are expected to be utilized indrug screening and regenerative medicine. However, hepatocyte-like cells have not been fully used

Background—Liver organoids show promise for development as a tissue replacement therapy for patients with end-stage liver disease, but efficient methods for introducing organoids into host livers have

Vascular tissue engineering has significant potential to make a major impact on a wide array of clinical problems. Continuedprogress in understanding basic vascular biology will be invaluable in makin

Stem cell technologies, especially patient-specific, induced stem cell pluripotency and directed differentiation,hold great promise for changing the landscape of medical therapies. Proper exploitation