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• Short-Term Microgravity Influences Cell Adhesion in Human Breast Cancer Cells 2025-01-25 With the commercialization of spaceflight and the exploration of space, it is important to understand the changes occurring in human cells exposed to real microgravity (r-mu g) conditions. We examined the influence of r-mu g, simulated microgravity (s-mu g, incubator random positioning machine (iRPM)), hypergravity (hyper-g), and vibration (VIB) on triple-negative breast cancer (TNBC) cells (MDA-MB-231 cell line) with the aim to study early changes in the gene expression of factors associated with cell adhesion, apoptosis, 文献案例

• Proliferation and performance of hybridoma cells in microgravity (7-IML-1) 2024-12-31 Endothelial cells play a crucial role in the pathogenesis of many diseases and are highly sensitive to low gravity conditions. Using a three-dimensional random positioning machine (clinostat) we investigated effects of simulated weightlessness on the human EA.hy926 cell line (4, 12, 24, 48 and 72 h) and addressed the impact of exposure to VEGF (10 ng/ml). Simulated microgravity resulted in an increase in extracellular matrix proteins (ECMP) and altered cytoskeletal components such as microtubules (alpha-tubulin) and intermediate filaments (cytokeratin). Within the initial 4 h, both simulated microgravity and VEGF, alone, enhanced the expression of ECMP (collagen type I, fibronectin, osteopontin, laminin) and flk-1 protein. 文献案例

• he effect of simulated microgravity on hybridoma cells 2024-12-31 ​The effect of clinostat-simulated microgravity on SP-2/0 and 1D6 hybridoma cells was studied. Clinorotation during 4–5 days at 1.5 rounds per minute decreased dramatically their proliferating capacity: the rotated cells divided less than once while control cells performed 4–5 divisions. They decreased the non-specific adhesion to tissue culture plastic, but increased the number of cell-to-cell contacts. Such phenomenological changes were accompanied with the alterations in pericellular glycosaminoglycans: 文献案例

• 模拟微重力对哺乳动物不同脑区神经组织细胞的影响研究 2024-10-11 宇宙环境对航天员的身体健康带来了一些不良影响。目前,关于空间环境,尤其是微重力对宇航员中枢神经系统影响的研究层出不穷。但是少有将不同脑区的微重力效应进行比较的研究进展。不同脑区在细胞组成、组织结构、功能作用等方面都存在差异,所以不同脑区对微重力的响应是否相同的问题也需要解决。研究地面模拟微重力效应对不同脑区组织形态学和凋亡的影响,是研究微重力效应的重要一环。 文献案例

• RCCS模拟微重力影响大鼠甲状腺滤泡上皮细胞生长特性和分泌功能的研究 2024-10-11 背景和目的我国载人航天工程已处于关键时期,要实现长期驻留太空的目标,维持航天员的健康、安全和高效的工作能力至关重要。航天飞行过程中的失重因素会导致航天员内分泌系统在内的各系统器官一系列生理病理变化。甲状腺是人体内最大的内分泌腺体,机体生长、发育和代谢活动受甲状腺激素的影响和调节,一旦发生病变会引起机体多系统各种代谢障碍。国外学者研究证实,航天失重对甲状腺功能和形态产生重要影响,国内则尚未见相关研究报道。本研究釆用微重力细胞培养系统(the rotary cell culture system,RCCS),研究模拟微重力... 文献案例

• RCCS模拟微重力影响小鼠成纤维细胞lncRNA及UVC辐射后创伤修复相关基因蛋白表达的研究 2024-10-11 背景和目的随着载人航天工程的飞速发展,越来越多的宇航员相继进入太空,并且在太空驻留时间不断延长,舱外活动日趋增多,宇航员发生意外创伤和应激损伤的几率相应增多。据研究报道,长期航天飞行过程中最常见的创伤为皮肤软组织伤。皮肤创伤的愈合过程是一个复杂而有序的生物学过程,涉及多种细胞、细胞因子和细胞外基质等错综复杂的网络作用。长链非编码RNA(Long non-coding RNA,lnc RNA)在表观遗传调控、转录调控以及转录后调控等方面发挥重要作用。 文献案例

• Simulated microgravity decreases apoptosis in fetal fibroblasts 2024-09-27 ​Space travel is a major challenge for human beings. Especially, the mechanisms through which space conditions might alter animal development have been questioned for a long time. The two major physical stress factors that are of relevance in this context are space radiation and weightlessness. While it has been extensively shown that high doses of ionizing radiation induce deleterious effects on embryonic development 文献案例

• Nanostructured substrate conformation can decrease osteoblast-like cell dysfunction in simulated microgravity conditions 2024-09-27 Cells in situ are surrounded with defined structural elements formed by the nanomolecular extracellular matrix (ECM), and at the same time subjected to different mechanical stimuli arising from variety of physiological processes. In this study, using a nanotextured substrate mimicking the structural elements of the ECM and simulated microgravity, we wanted to develop a multifactorial model and understand better what guides cells in determining the morphological cell response. 文献案例

• Physiological Responses of Jurkat Lymphocytes to Simulated Microgravity Conditions 2024-09-27 The presence of microgravity conditions deeply affects the human body functions at the systemic, organ and cellular levels. This study aimed to investigate the effects induced by simulated-microgravity on non-stimulated Jurkat lymphocytes, an immune cell phenotype considered as a biosensor of the body responses, in order to depict at the cellular level the effects of such a peculiar condition. Jurkat cells were grown at 1 g or on random positioning machine simulating microgravity. On these cells we performed: morphological, 文献案例

• Dexamethasone Inhibits Spheroid Formation of Thyroid Cancer Cells Exposed to Simulated Microgravity 2024-09-27 Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target combinations for future therapies. By using the synthetic glucocorticoid dexamethasone (DEX), 文献案例

• Characterization of Human Chondrocytes Exposed to Simulated Microgravity 2024-09-27 Background: Tissue engineering is a strategy of cartilage regeneration, but scaffolds, required for 3D growth of chondrocytes, are still a problem. Methods: Searching for possibilities to improve scaffold-free engineering of cartilage, we characterized human chondrocytes incubated on a random positioning machine (RPM) to simulate microgravity (mu g). Results: When cultured in simulated mu g, human chondrocytes start forming 3D cell assemblies within 5 days. After 24h 文献案例

• Common Effects on Cancer Cells Exerted by a Random Positioning Machine and a 2D Clinostat 2024-07-10 In this study we focused on gravity-sensitive proteins of two human thyroid cancer cell lines (ML-1, RO82-W-1), which were exposed to a 2D clinostat (CLINO), a random positioning machine (RPM) and to normal 1g-conditions. After a three (3d)-or seven-day-culture (7d) on the two devices, we found both cell types growing three-dimensionally within multicellular spheroids (MCS) and also cells remaining adherent (AD) to the culture flask, while 1g-control cultures only formed adherent monolayers...... 文献案例